Myasthenia gravis is an autoimmune disease which affects the neuromuscular junction tissue, i.e., it interrupts the connection between nerves and muscles, causing paralysis, fatigue, and weakening of skeletal muscles.

The underlying cause of Myasthenia gravis (MG) is that the immune system starts to attack its own cells, causing transmission errors between the nerve impulses and skeletal muscles which disrupts the proper coordination in the body.