• Hoffmann Bromamide Degradation reaction occurs by treating an amide with bromine in the presence of the aqueous or ethanolic solution of sodium hydroxide.

• In this reaction, migration of an alkyl or aryl group happens from the carbonyl carbon of the amide to the nitrogen atom of the same amide.

• Hence the amine formed contains one carbon less than that of the reactant amide.

(i) ArNH₂ (iii) ArNO₂ and (iv) ArCH₂NH₂ do not undergo this degradation reaction.