• Gabriel synthesis is only applicable on the synthesis for aliphatic primary amines as this is a nucleophillic substitution reaction which follows several steps to form primary amines (addition of ethanolic or alcoholic KOH/NaOH then heating with alkyl halide and then finally alkaline hydrolysis).

• Aryl halides like (ii) 2-Phenylethylamine(iii) N-methylbenzylamine and (iv) Aniline

do not undergo nucleophillic substitution reactons and therefore cannot be prepared by his method