A primary amine, RNH 2 can be reacted with CH 3 —X to get secondary amine, R—NHCH 3 but the only disadvantage is that 3° amine and quaternary ammonium salts are also obtained as side products. Can you suggest a method where RNH 2 forms only 2° amine?

Question

Philoid · Accepted Answer

RNH₂ can form only 2° amine when carbylamine reaction is done followed by treatment with H₂/Pd.

When RNH₂ is heated with chloroform and KOH, isocyanides or carbylamines are formed. Isocyanides or carbylamines are then converted to 2° amine by H₂/Pd.

The chemical reaction involved in this case is:

RNH₂ + KOH + CHCl₃ + heat → RNC + H₂/Pd → R-NH-CH₃

A primary amine, RNH2 can be reacted with CH3—X to get secondary amine, R—NHCH3 but the only disadvantage is that 3° amine and quaternary ammonium salts are also obtained as side products. Can you suggest a method where RNH2 forms only 2° amine?

A primary amine, RNH₂ can be reacted with CH₃—X to get secondary amine, R—NHCH₃ but the only disadvantage is that 3° amine and quaternary ammonium salts are also obtained as side products. Can you suggest a method where RNH₂ forms only 2° amine?