A primary amine, R—NH 2 can be reacted with alkyl halide, RX, to get secondary amine, R 2 NH, but the only disadvantage is that 3° amine and quaternary ammonium salts are also obtained as side products. Can you suggest a method where CH 3 NH 2 forms only 2° amine?

Question

Philoid · Accepted Answer

Yes, we can convert CH₃NH₂ to a 2⁰ amine without getting any side products.

This reaction is called condensation reaction or amidation of alcohol.

This reaction involves the reaction between primary alcohol and a primary amine in the presence of a catalyst [RhH(PPh₃)₄] and yield of secondary amine is greater than 98%.

Amidation of alcohols.

A primary amine, R—NH2 can be reacted with alkyl halide, RX, to get secondary amine, R2NH, but the only disadvantage is that 3° amine and quaternary ammonium salts are also obtained as side products. Can you suggest a method where CH3NH2 forms only 2° amine?

A primary amine, R—NH₂ can be reacted with alkyl halide, RX, to get secondary amine, R₂NH, but the only disadvantage is that 3° amine and quaternary ammonium salts are also obtained as side products. Can you suggest a method where CH₃NH₂ forms only 2° amine?