Note: In the following questions a statement of assertion followed by a statement of reason is given. Choose the correct answer out of the following choices.
Assertion : Competitive inhibitors compete with natural substrate for their attachment on the active sites of enzymes.
Reason : In competitive inhibition, inhibitor binds to the allosteric site of the enzyme.
• Competitive inhibitors (drugs) compete with the natural suitable substrates for their attachment of on the active sites of enzymes.
• These kinds of drug block the binding active site of the enzyme & somehow prevents the linkage b/w enzyme & substrate inhibiting the natural catalytic activity of the enzyme.
• The reason statement, here is wrong because only non-competitive inhibitors ( different than competitive drugs) bind to a different site than the active site which is called the allosteric site of an enzyme resulting a change of shape in the active site of that enzyme in such a way it becomes impossible for the substrate to identify the active site and to bind to it.
• Thus these type of inhibitors (non-competitive) do not directly deal with the active site of the enzyme.
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