Give plausible explanation for each of the following: Cyclohexanone forms cyanohydrin in good yield but 2,2,6-trimethylcyclohexanone does not.

Question

Philoid · Accepted Answer

cyclohexanone forms cyanohydrin in good yield because the ketonic group has very less steric hindrance at both the ortho position but 2,2,6 tri methyl cyclohexanone have high steric hindrance which reduces the attack from CN nucleophile.

(High steric hindrance)

Give plausible explanation for each of the following:Cyclohexanone forms cyanohydrin in good yield but 2,2,6-trimethylcyclohexanone does not.

Give plausible explanation for each of the following:
Cyclohexanone forms cyanohydrin in good yield but 2,2,6-trimethylcyclohexanone does not.