The tissue or organ the microbes enter depends on the point of entry. For examples the microbes of tuberculosis enter through the nose and infect the lungs. If they enter through the mouth they stay in the gut lining or enter the liver like viruses that cause jaundice.

Exceptions to this case is also seen where the microbes no matter the site of entry reaches the tissue targeted for infection. For example the malaria causing microbe enters the liver and then goes to the red blood cells.